Papers
Showing 164 published or preprint papers authored by the Bennett Institute.
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Data-Driven Identification of Potentially Successful Intervention Implementations Using 5 Years of Opioid Prescribing Data
By applying one of our existing analysis tools to a national dataset, we were able to rank NHS organisations by reduction in opioid prescribing rates. Highly ranked organisations are candidates for further qualitative research into intervention design and implementation.
Status: Published
Categories
- OpenPrescribing
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Incidence and treatment of group A streptococcal infections during covid-19 pandemic and 2022 outbreak
Investigation of the effect of the covid-19 pandemic on the number of patients with group A streptococcal infections and related antibiotic prescriptions
Status: Published
Categories
- OpenSAFELY
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OpenSAFELY: Effectiveness of COVID-19 vaccination in children and adolescents
We conducted a matched sequential trials observational study to assess the safety and effectiveness of first and second dose BNT162b2 COVID-19 vaccination in children and adolescents in England.
Status: Preprint
Categories
- OpenSAFELY
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Clinical coding of long COVID in primary care 2020–2023 in a cohort of 19 million adults
Incidence and differences in demographic and clinical characteristics in recorded long COVID in primary care records in England.
Status: Published
Categories
- OpenSAFELY
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Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations
To examine the impact of the pandemic on deprivation-related inequalities in hospitalisations for CVD conditions in Denmark and England between March 2018 and December 2021.
Status: Preprint
Categories
- OpenSAFELY
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Impact of the COVID-19 pandemic on antidepressant prescribing with a focus on people with learning disability and autism: an interrupted time series analysis in England using OpenSAFELY-TPP
COVID-19 lockdowns led to increased reports of depressive symptoms in the general population and impacted the health and social care services of people with learning disability and autism. We explored whether the COVID-19 pandemic had an impact on antidepressant prescribing trends within these and the general population.
Status: Published
Categories
- OpenSAFELY
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Impact of long COVID on health-related quality-of-life: an OpenSAFELY population cohort study using patient-reported outcome measures (OpenPROMPT)
We aimed to evaluate and estimate the differences in health impacts of long COVID across sociodemographic categories and quantify this in Quality-Adjusted Life-Years (QALYs), widely used measures across health systems.
Status: Published
Categories
- OpenSAFELY
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Identification of patients undergoing chronic kidney replacement therapy in primary and secondary care data
Identification of people receiving chronic kidney replacement therapy using primary and secondary care records compared with gold standard registry data.
Status: Published
Categories
- OpenSAFELY
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The impact of COVID-19 on azathioprine, leflunomide and methotrexate monitoring, and factors associated with change in monitoring rate
This study investigated whether disease-modifying anti-rheumatic drug (DMARD) safety monitoring was affected during the COVID-19 pandemic, with additional focus on effects within key health inequality groups.
Status: Published
Categories
- OpenSAFELY
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The impact of COVID-19 on medication reviews in English primary care
This study investigated whether the rate of medication reviews in primary care were affected during the COVID-19 pandemic, with breakdown by regional, clinical and demographic subgroups.
Status: Published
Categories
- OpenSAFELY
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Comparative safety and effectiveness of Pfizer BA.4-5 versus Sanofi during the spring 2023 COVID-19 booster vaccination programme in England
A comparison of the Pfizer BA.4-5 and Sanofi vaccines for protecting against Covid-19 during Spring 2023 booster programme in England
Status: Preprint
Categories
- OpenSAFELY
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Impact of vaccination on the association of COVID-19 with cardiovascular diseases
We quantified associations between COVID-19 diagnosis and cardiovascular diseases in different vaccination and variant eras using linked electronic health records for ~40% of the English population.
Status: Published
Categories
- OpenSAFELY
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During the COVID-19 pandemic 20 000 prostate cancer diagnoses were missed in England
This study investigated the effect of the COVID-19 pandemic on prostate cancer incidence, prevalence, and mortality in England. The pandemic led to 20 000 missed prostate cancer diagnoses in England alone.
Status: Published
Categories
- OpenSAFELY
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Measuring BMI in 22 million patients in England
This study describes the use of four derivations of BMI in OpenSAFELY.
Status: Published
Categories
- OpenSAFELY
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Weight trends amongst adults with diabetes or hypertension during the COVID-19 pandemic
Amongst adults living in England with T2D and/or hypertension, rapid pandemic weight gain was more common amongst females, younger adults, those living in more deprived areas, and those with mental health conditions.
Status: Published
Categories
- OpenSAFELY
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Safety of direct-acting oral anticoagulant (DOAC) prescribing
This study aimed to identify the proportion of those prescribed a DOAC with recorded: weight, estimated Glomerular Filtration Rate (eGFR), creatinine, creatinine clearance (CrCl) and atrial fibrillation (AF). In those with recorded AF and CrCl prescribed the study aimed to identify the proportion with a recommended DOAC dose.
Status: Published
Categories
- OpenSAFELY
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OpenSAFELY: a platform for analysing electronic health records designed for reproducible research
This paper describes OpenSAFELY's reproducibility-by-design approach in detail.
Status: Published
Categories
- OpenSAFELY
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Trends in inequalities in avoidable hospitalisations across the COVID-19 pandemic
We determine whether periods of disruption were associated with increased ‘avoidable’ hospital admissions and wider social inequalities in England.
Status: Published
Categories
- OpenSAFELY