Papers
Showing 162 published or preprint papers authored by the Bennett Institute.
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Uptake of service specific codes for the COVID oximetry @Home Pulse Oximetry service: an analysis of 57 million patients' primary care records using OpenSAFELY
This study investigated clinical coding used to support remote pulse oximetry services, with breakdown by regional, clinical and demographic subgroups.
Status: Preprint
Categories
- OpenSAFELY
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Trends and variation in andexanet alfa for the reversal of direct oral anticoagulants in NHS Trusts in England
This study explored trends and variation in the uptake of andexanet alfa for the reversal of direct oral anticoagulants in NHS Trusts in England.
Status: Preprint
Categories
- OpenPrescribing
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Using Laboratory Test Results for Surveillance During a New Outbreak of Acute Hepatitis in 3-Week- to 5-Year-Old Children in the United Kingdom, the Netherlands, Ireland, and Curaçao: Observational Cohort Study
This study explored a simple federated data analytics method to search for evidence of unreported cases of pediatric hepatitis.
Status: Published
Categories
- OpenSAFELY
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Primary care coding activity related to the use of online consultation systems or remote consulting
We explore general practice coding activity associated with the use of online consultation systems in terms of trends, COVID-19 effect, variation and quality.
Status: Published
Categories
- OpenSAFELY
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Impact of COVID-19 on recorded blood pressure screening and hypertension management in England
We describe the impact of the COVID-19 pandemic on blood pressure screening and hypertension management in England.
Status: Published
Categories
- OpenSAFELY
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Therapeutics Dataset from COVID-19 Medicine Delivery Units in England
This paper assessed the content and data quality of the COVID-19 Therapeutics dataset within OpenSAFELY, with a specific focused on therapeutics provided in outpatient settings by CMDUs.
Status: Preprint
Categories
- OpenSAFELY
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The safety of antivirals and neutralising monoclonal antibodies used in prehospital treatment of Covid-19
This proof-of-principle pharmacovigilance study used Electronic Health Record (EHR) data to examine the safety of sotrovimab, paxlovid and molnupiravir in prehospital treatment of Covid-19
Status: Published
Categories
- OpenSAFELY
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Consistency, completeness and external validity of ethnicity recording in NHS primary care records: a cohort study in 25 million patients’ records at source using OpenSAFELY
We describe the completeness and consistency of primary care ethnicity recording in the OpenSAFELY-TPP database, containing linked primary care and hospital records in >25 million patients in England. We also compared the ethnic breakdown in OpenSAFELY-TPP with that of the 2021 UK census.
Status: Published
Categories
- OpenSAFELY
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Changes in sick notes associated with COVID-19 from 2020 to 2022: a cohort study in 24 million primary care patients in OpenSAFELY-TPP
This study quantified the sick note rate in people with documented SARS-CoV-2 infection or COVID-19 diagnosis in 2020, 2021 and 2022 overall, by demographics, and by time since diagnosis. We also used adjusted Cox regression to compare the sick note rate to the general population.
Status: Published
Categories
- OpenSAFELY
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Effectiveness of mRNA COVID-19 Vaccines as First Booster Doses in England
We estimate the effectiveness of boosting with BNT162b2 or mRNA-1273 COVID-19 vaccines compared with no boosting in eligible adults who had received two primary course vaccine doses in England.
Status: Published
Categories
- OpenSAFELY
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Changes in opioid prescribing during the COVID-19 pandemic in England
This study described changes in prevalent and new opioid prescribing during the COVID-19 pandemic, overall, among people in care homes, and stratified by demographics.
Status: Published
Categories
- OpenSAFELY
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Trends in weight gain recorded in English primary care before and during the Coronavirus-19 pandemic: An observational cohort study using the OpenSAFELY platform
This study uses OpenSAFELY to investigate patterns of weight change before and during the pandemic in England and describe which groups were most likely to have experienced unhealthy patterns of weight gain.
Status: Published
Categories
- OpenSAFELY
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Healthcare utilisation in people with long COVID
This study aims to assess the healthcare utilisation of individuals with long COVID.
Status: Published
Categories
- OpenSAFELY
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Exploring Prior Antibiotic Exposure Characteristics for COVID-19 Hospital Admission Patients
The aim of this study was to explore the relationship between COVID-19 infection severity and exposure to two or more prior antibiotic prescriptions. The primary goal was to more accurately describe the characteristics of antibiotic prescribing and its association with severe COVID-19 outcomes, taking into account various risk factors such as increased comorbidities in this population, age, sex, and ethnicity.
Status: Published
Categories
- OpenSAFELY
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Data-Driven Identification of Potentially Successful Intervention Implementations Using 5 Years of Opioid Prescribing Data
By applying one of our existing analysis tools to a national dataset, we were able to rank NHS organisations by reduction in opioid prescribing rates. Highly ranked organisations are candidates for further qualitative research into intervention design and implementation.
Status: Published
Categories
- OpenPrescribing
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Incidence and treatment of group A streptococcal infections during covid-19 pandemic and 2022 outbreak
Investigation of the effect of the covid-19 pandemic on the number of patients with group A streptococcal infections and related antibiotic prescriptions
Status: Published
Categories
- OpenSAFELY
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OpenSAFELY: Effectiveness of COVID-19 vaccination in children and adolescents
We conducted a matched sequential trials observational study to assess the safety and effectiveness of first and second dose BNT162b2 COVID-19 vaccination in children and adolescents in England.
Status: Preprint
Categories
- OpenSAFELY
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Clinical coding of long COVID in primary care 2020–2023 in a cohort of 19 million adults
Incidence and differences in demographic and clinical characteristics in recorded long COVID in primary care records in England.
Status: Published
Categories
- OpenSAFELY